abstract：:This work demonstrates Box-Behnken design (BBD)'s capability in exploring scientific principles governing a process, different from its use in process optimisation. We have investigated nanoprecipitation (NP) of temozolomide with polycaprolactone. Five factors, surfactant, stirring speed (SS), dropping rate (DR), phas...

journal_title：Journal of microencapsulation

authors： Singh Y,Ojha P,Srivastava M,Chourasia MK

更新日期：2015-01-01 00:00:00

abstract：:The purpose of the present study was to provide further insights on the applicability of microencapsulation using emulsification method, to immobilise Clostridium acetobutylicum ATCC 824 spores, for biobutanol production. The encapsulated spores were revived using heat shock treatment and the fermentation efficiency o...

journal_title：Journal of microencapsulation

authors： Rathore S,Wan Sia Heng P,Chan LW

更新日期：2015-01-01 00:00:00

abstract：:The purpose of this study was to design and characterise an oral mucoadhesive micellar drug carrier. In this regard, a mucoadhesive hydrophobic cationic aminocellulose was easily synthesised under mild homogeneous conditions with high yield. The cellulose derivative resulted in strongly improved mucoadhesive propertie...

journal_title：Journal of microencapsulation

authors： Songsurang K,Siraleartmukul K,Muangsin N

更新日期：2015-01-01 00:00:00

abstract：:Redox-responsive magnetic protein microcapsules with Fe3O4 magnetic nanoparticles (MNPs) encapsulated inside have been obtained using a facile, cost-effective and fast sonochemical method from hen egg white proteins. Such prepared redox-responsive magnetic hen egg white protein microcapsules (MHEWPMCs) could be easily...

journal_title：Journal of microencapsulation

authors： Zhong S,Cui X,Tian F

更新日期：2015-01-01 00:00:00

abstract：:This article describes the physicochemical properties of chitosan-coated liposomes containing skin-protecting agents, coenzyme Q10 and alpha-lipoic acid (CCAL). CCAL had a spherical shell-core structure and liposomes inverted the surface charge from negative to positive after coating with chitosan. Compared with the u...

journal_title：Journal of microencapsulation

authors： Zhao GD,Sun R,Ni SL,Xia Q

更新日期：2015-01-01 00:00:00

abstract：:N-lauroyl chitosan (NLCS) conjugates with different degrees of substitution (DS) of lauroyl group were synthesized and used to prepare surface modified poly(lactic-co-glycolic) acid (NLCS-PLGA) nanoparticles via hydrophobic interaction and ionic bond force. NLCS-PLGA nanoparticles had spherical shape with shell-core s...

journal_title：Journal of microencapsulation

authors： Li J,Zhou P,Wang Y,Chen H,Zhang C,Li R,Yang X,Wang Y

更新日期：2014-01-01 00:00:00

abstract：:Biodegradable hollow capsules filled with fluorescently labelled bovine serum albumin (BSA) as a model drug were prepared via layer-by-layer (LbL) self-assembly of type-I collagen (COL) and hyaluronic acid (HA) using calcium carbonate micro-particles and co-precipitation method. Capsules loaded with fluorescein isothi...

journal_title：Journal of microencapsulation

authors： Sousa F,Kreft O,Sukhorukov GB,Möhwald H,Kokol V

更新日期：2014-01-01 00:00:00

abstract：CONTEXT:Quercetin (QUE) is a flavonoid with antioxidant/anti-inflammatory properties, poorly absorbed when orally administered. OBJECTIVES:To prepare chitosan/xanthan gum microparticles to increase QUE oral bioavailability and optimize its release in the colon. MATERIALS AND METHODS:Chitosan/xanthan gum hydrogel embe...

journal_title：Journal of microencapsulation

authors： Caddeo C,Nácher A,Díez-Sales O,Merino-Sanjuán M,Fadda AM,Manconi M

更新日期：2014-01-01 00:00:00

abstract：:This study demonstrates the feasibility of using a single-capillary electrospray (ES) system to generate novel alpha-lipoic acid encapsulated poly(ethylene oxide)-chitosan (ALA/PEO/CS) particles with a monodispersed diameter. Scanning electron microscopic images (SEM) and dynamic light scattering (DLS) results indicat...

journal_title：Journal of microencapsulation

authors： Bai MY,Hu YM

更新日期：2014-01-01 00:00:00

abstract：:The objective of this study was selection of most influential variable for the preparation of gastro adhesive nanoparticles of acyclovir. Effect of formulation and processing variables on various response variables were studied by a Taguchi standard orthogonal array L8 design. Independent variables studied were the am...

journal_title：Journal of microencapsulation

authors： Kharia AA,Singhai AK

更新日期：2014-01-01 00:00:00

abstract：CONTEXT:Solid lipid nanoparticles (SLNs) can efficiently and efficaciously incorporate anti-cancer agents. OBJECTIVE:To prepare and characterise tamoxifen (TAM)-loaded SLNs. MATERIALS AND METHODS:Glyceryl monostearate, Tween-80, and trehalose were used in SLNs. SLNs were tested via dynamic light scattering (DLS), tra...

journal_title：Journal of microencapsulation

authors： Lakkadwala S,Nguyen S,Lawrence J,Nauli SM,Nesamony J

更新日期：2014-01-01 00:00:00

abstract：:The aim of the present study is to construct a type of polyion complex micelles made of PF127-PEI copolymer and cholic acid (CA) and to evaluate the potential of this type of micelles as a targeted drug delivery system for paclitaxel (PTX). To further improve the targeting capability of micelles, folate was also incor...

journal_title：Journal of microencapsulation

authors： Li Y,Zhou Y,De B,Li L

更新日期：2014-01-01 00:00:00

abstract：AIM:To study the effect of poly(d,l-lactic-co-glycolic acid) (PLGA) microparticles (MPs) preparation techniques on particle physical characterization with special emphasis on burst drug release. METHODS:A basic drug clozapine was used in combination with acid-terminated PLGA. Two approaches for MP preparation were com...

journal_title：Journal of microencapsulation

authors： Ishak RA,Mortada ND,Zaki NM,El-Shamy Ael-H,Awad GA

更新日期：2014-01-01 00:00:00

abstract：:This article describes the development of a freeze-dried formulation of chitosan (CS) nanocapsules containing docetaxel (DCX) and the evaluation of its efficacy in the NCI-H460 cancer cell line. More specifically, two prototypes of nanocapsules differing in their coating, CS alone or in combination with poloxamer 188 ...

journal_title：Journal of microencapsulation

authors： Lozano MV,Esteban H,Brea J,Loza MI,Torres D,Alonso MJ

更新日期：2013-01-01 00:00:00

abstract：:Documented to exhibit cytotoxicity and poor oral bioavailability, alpha-mangostin was encapsulated into PLGA microspheres with optimization of formulation using response surface methodology. Mixed levels of four factors Face central composite design was employed to evaluate critical formulation variables. With 30 runs...

journal_title：Journal of microencapsulation

authors： Elsaid Ali AA,Taher M,Mohamed F

更新日期：2013-01-01 00:00:00

abstract：:We studied a model system of controlled drug release using beta-carotene and κ-carrageenan/NaCMC hydrogel as a drug and a device, respectively. Different concentrations of genipin were added to crosslink the beta-carotene loaded beads by using the dripping method. Results have shown that the cross-linked beads possess...

journal_title：Journal of microencapsulation

authors： Hezaveh H,Muhamad II,Noshadi I,Shu Fen L,Ngadi N

更新日期：2012-01-01 00:00:00

abstract：:Nanoparticles prepared of human serum albumin (HSA) represent promising carriers for drug delivery. Desolvating procedure is a common method to obtain protein-based particles. However process parameters have a great influence on size, size distribution and particle yield of the resulting formulation. Therefore, it is ...

journal_title：Journal of microencapsulation

authors： Storp Bv,Engel A,Boeker A,Ploeger M,Langer K

更新日期：2012-01-01 00:00:00

abstract：:We demonstrate the microencapsulation of a double-base (DB) rocket propellant stabiliser, 2-nitrodiphenylamine (2-NDPA), that can potentially increase the shelf life of DB rocket propellants. Poly(lactide-co-glycolide) (PLG) microspheres loaded with 2-NDPA were prepared using the oil-in-water emulsion technique. The m...

journal_title：Journal of microencapsulation

authors： Shorty M,Singh S,Jebrail FF,Andrews MJ

更新日期：2012-01-01 00:00:00

abstract：CONTEXT:Coated whey protein micro-beads may improve probiotic protection and provide delayed cell-release mechanisms. OBJECTIVE:Lactobacillus rhamnosus GG was encapsulated in whey protein micro-beads by droplet extrusion with coating via electrostatic deposition: primary-polysaccharide and secondary-whey protein. MAT...

journal_title：Journal of microencapsulation

authors： Doherty SB,Auty MA,Stanton C,Ross RP,Fitzgerald GF,Brodkorb A

更新日期：2012-01-01 00:00:00

abstract：:One of the main challenges in radiation oncology is to overcome the resistance of cancer cells against treatment by molecular targeted approaches. Among the most promising targets is the inhibitor of apoptosis protein survivin, known to be associated with increased tumour aggressiveness and therapy resistance. The obj...

journal_title：Journal of microencapsulation

authors： Gaca S,Reichert S,Rödel C,Rödel F,Kreuter J

更新日期：2012-01-01 00:00:00

abstract：:The effects of different loading procedures of magnetic nanoparticles (MNs) on the structure and physicochemical properties of cisplatin magnetic liposomes were investigated by X-ray diffraction, infrared spectroscopy, transmission electron microscopy, and fluorescence spectroscopy. 1, 2-Dipalmitoyl-sn-glycero-3-Phosp...

journal_title：Journal of microencapsulation

authors： Wang L,Yang CQ,Wang J

更新日期：2012-01-01 00:00:00

abstract：:An extrusion-based encapsulation process has been developed for making salt grain-sized iron premix for salt fortification. The first step of extrusion agglomeration process has been studied and reported previously. The focus of this study is on the optimisation of the colour-masking and polymer coating steps. Several...

journal_title：Journal of microencapsulation

authors： Yadava D,Olive Li Y,Diosady LL,Wesley AS

更新日期：2012-01-01 00:00:00

abstract：:Microspheres, including microcapsules and cells or beads, are widely used to produce many functional products. Information about their mechanical properties is essential to understanding their performance during manufacturing, processing and end-use applications. The mechanical characterization of microspheres require...

journal_title：Journal of microencapsulation

authors： Mercadé-Prieto R,Zhang Z

更新日期：2012-01-01 00:00:00

abstract：PURPOSE:This investigation was undertaken to develop glyceryl monostearate (Geleol)-based solid lipid nanoparticles (SLNs) of a hydrophilic drug ciprofloxacin HCl. METHODS:Hansen's solubility parameter study was carried out in screening of a suitable carrier and solvent system. Subsequently, SLNs were prepared by solv...

journal_title：Journal of microencapsulation

authors： Shah M,Agrawal Y

更新日期：2012-01-01 00:00:00

abstract：:To overcome the recurrence problem in bladder tumours; nanoparticles with positive surface charge may improve interaction with biological membranes for intravesical administration. The aim of this study was to design, develop and evaluate (in vitro-in vivo) cationic nanoparticles based on chitosan, poly-L-lysine or po...

journal_title：Journal of microencapsulation

authors： Erdoğar N,Iskit AB,Mungan NA,Bilensoy E

更新日期：2012-01-01 00:00:00

abstract：:To improve poor water solubility of cyclosporine A (CsA), hydroxypropyl-beta-cyclodextrin (HPβCD) was incorporated into the nanoparticle formulation. Solid complexes of CsA with HPβCD in different ratios were prepared by the kneading method. CsA containing alone or in combination with HPβCD in poly-lactide-co-glycolid...

journal_title：Journal of microencapsulation

authors： Aksungur P,Demirbilek M,Denkbaş EB,Unlü N

更新日期：2012-01-01 00:00:00

abstract：:This study aims to formulate a microparticle-based system that protects the protein from the harsh gastric conditions and also provides appropriate uptake via M cells for desired immune response upon oral administration. The formulation was derived using a valid statistical model, analysed by JMP® (SAS). The average s...

journal_title：Journal of microencapsulation

authors： Chablani L,Tawde SA,D'Souza MJ

更新日期：2012-01-01 00:00:00

abstract：:Transplantation of cells genetically modified to produce neurotrophins is a promising spinal cord repair strategy. Previously we showed that fibroblasts engineered to produce brain-derived neurotrophic factor (Fb/BDNF) microencapsulated in alginate survive, continue to grow and express bioactive BDNF. We here compared...

journal_title：Journal of microencapsulation

authors： Francis NL,Shanbhag MS,Fischer I,Wheatley MA

更新日期：2011-01-01 00:00:00

abstract：:In this study, recombinant human interleukin-2 (rhIL-2) containing poly(lactic-co-glycolic acid) (PLGA) microparticles were prepared for pulmonary administration by modified w/o/w double emulsion solvent extraction method and the effects of various formulation parameters on the physicochemical properties of the microp...

journal_title：Journal of microencapsulation

authors： Devrim B,Bozkir A,Canefe K

更新日期：2011-01-01 00:00:00

abstract：:In this study, we evaluated a system for oral vaccine delivery, consisting of liposomes coated first with a layer of tremella and then with an outer layer of acid-induced alginate. In vitro release studies showed that the triple layer of alginate-tremella-liposomes was more resistant to an acidic pH and modulated the ...

journal_title：Journal of microencapsulation

authors： Cheng HC,Chang CY,Hsieh FI,Yeh JJ,Chien MY,Pan RN,Deng MC,Liu DZ

更新日期：2011-01-01 00:00:00

abstract：:Low molecular weight heparin (LMWH)-loaded flexible liposomes (flexosomes) were formulated for transdermal delivery, and their physicochemical and pharmacokinetic parameters were compared with LMWH-loaded ethosomes. Flexosomes had similar particle size compared with ethosomes, but their deformability was higher than t...

journal_title：Journal of microencapsulation

authors： Song YK,Hyun SY,Kim HT,Kim CK,Oh JM

更新日期：2011-01-01 00:00:00

abstract：:Solid lipid nanoparticles (SLNs) and nanosuspensions (NSs) have shown great promise for improving bioavailability of poorly water-soluble drugs. This study was aimed to develop SLNs and NS of Saquinavir (SQ) for improvement in bioavailability. These formulations were characterized and their pharmacokinetics and biodis...

journal_title：Journal of microencapsulation

authors： Dodiya SS,Chavhan SS,Sawant KK,Korde AG

更新日期：2011-01-01 00:00:00

abstract：:Graft copolymer polyethylenimine-graft-poly(N-vinylpyrrolidone) (PEI-g-PVP) was prepared by coupling mono carboxyl-terminated PVP (PVP-COOH) with PEI using N,N'-dicyclohexylcarbodiimide (DCC) and N-hydroxysuccinimide (NHS) as coupling agents. In aqueous medium, PVP-g-PEI can self-assemble into stable polyion complex m...

journal_title：Journal of microencapsulation

authors： Yuan J,Luo Y,Gao Q

更新日期：2011-01-01 00:00:00

abstract：:In this study, we formulated a microparticulate melanoma cancer vaccine via the transdermal route. The vaccine was delivered using microneedle-based Dermaroller® which is available for cosmetic purposes. Unlike subcutaneous injections, administration using microneedles is painless and in general can increase the perme...

journal_title：Journal of microencapsulation

authors： Bhowmik T,D'Souza B,Shashidharamurthy R,Oettinger C,Selvaraj P,D'Souza MJ

更新日期：2011-01-01 00:00:00

abstract：:Multilamellar liposomes incorporating essential oil of Brazilian cherry (Eugenia uniflora L.) leaves were produced by dry film hydration. Gas chromatography demonstrated the compounds found in the essential oil were effectively incorporated in the aqueous dispersions of liposomes. Differential scanning calorimetry ana...

journal_title：Journal of microencapsulation

authors： Yoshida PA,Yokota D,Foglio MA,Rodrigues RA,Pinho SC

更新日期：2010-01-01 00:00:00

abstract：:The effect of lecithin and starch on viability of alginate encapsulated probiotics was determined at different temperatures. Probiotic organisms (1% v/v>10Log CFU ml(-1)) were encapsulated using alginate (2% w/v), gelatinized starches (2% w/v) and lecithin (0-4% w/v) and stored in sealed containers at 4, 23 and 37 deg...

journal_title：Journal of microencapsulation

authors： Donthidi AR,Tester RF,Aidoo KE

更新日期：2010-01-01 00:00:00

abstract：:In this work we have examined the ability of various lipopolyplexes to deliver genes into liver cancer cells. We evaluated different parameters such as the protocol of preparation, the lipid/DNA molar ratio, and the molecular weight and type of PEI, to optimize the formulation to achieve high transfection activity. Ou...

journal_title：Journal of microencapsulation

authors： Tros de Ilarduya C,García L,Düzgünes N

更新日期：2010-01-01 00:00:00

abstract：:The sustained delivery of multiple agents to the lung offers potential benefits to patients. This study explores the preparation of highly respirable dual-loaded spray-dried double emulsions. Spray-dried powders were produced from water-in-oil-in-water (w/o/w) double emulsions, containing salbutamol sulphate and/or be...

journal_title：Journal of microencapsulation

authors： Learoyd TP,Burrows JL,French E,Seville PC

更新日期：2010-01-01 00:00:00

abstract：:A combined approach based on drug cyclodextrin (CD) complexation and loading into PLGA nanoparticles (NP) has been developed to improve oxaprozin therapeutic efficiency. This strategy exploits the solubilizing and stabilizing properties of CDs and the prolonged-release and targeting properties of PLGA NPs. Drug-loaded...

journal_title：Journal of microencapsulation

authors： Mura P,Maestrelli F,Cecchi M,Bragagni M,Almeida A

更新日期：2010-01-01 00:00:00

abstract：:Co-flowing media of a polymeric solution (30 wt% polymethylsilsesquioxane in ethanol) and a ceramic suspension (10 wt% alumina in glycerol) were subjected to an electric field. The flow rates of the media (10-30 microL min(-1)) and the applied voltage (0-11 kV) were varied systematically during the experimentation by ...

journal_title：Journal of microencapsulation

authors： Nangrejo M,Ahmad Z,Edirisinghe M

更新日期：2010-01-01 00:00:00